Study of DNA modifications and the mechanisms that regulate gene expression
through direct sequencing with Oxford Nanopore® technology.
Epigenomics studies the mechanisms that regulate gene expression without modifying the DNA sequence.
Thanks to Oxford Nanopore technology, it is possible to directly analyze different types of epigenetic modifications on native DNA, without bisulfite treatment such as bisulfite conversion or reducing bias linked to PCR amplification.
This approach enables examining epigenetic modifications in their native genomic context, offering a more complete picture of the gene expression regulation mechanisms.
Epigenomic sequencing is performed on the Oxford Nanopore Technologies® platform, which enables direct detection of base modifications during sequencing without additional chemical treatments.
Learn more on the dedicated Nanopore Sequencing → page.
Direct detection of base modifications on native DNA through long-read sequencing.
Epigenetic modification analysis on cell-free DNA (cfDNA) circulating for liquid biopsy-based research projects.
When a base is modified, it generates a distinct ionic current signal relative to the unmodified base, allowing identification of different types of epigenetic modifications:
The most studied epigenetic modification, associated with gene silencing and genome stability.
Intermediate modification in active demethylation, associated with gene expression dynamics.
Modification present in prokaryotes and associated with specific biological processes.
Modification associated with specific mechanisms in both prokaryotes and eukaryotes.
We offer a fully end-to-end service tailored to research needs.
Our team supports the client from experimental design consultation through to biological interpretation of results.
Samples prepared according to agreed specifications to ensure optimal quality for epigenomic analysis.
Full support in experimental preparation and complete workflow management:
The standard bioinformatics pipeline includes:
If requested, we can manage the upload of raw data to public repositories.
We can manage the upload of raw data to public repositories and provide support for biological interpretation of results.
Epigenomic analysis enables studying the mechanisms of gene expression regulation and DNA modifications across diverse biological contexts.
Study of the mechanisms that control and influence gene expression.
Analysis of DNA modifications associated with epigenetic alterations and development of diverse pathological processes.
Study of genomic imprinting, chromosomal inactivation and epigenetic processes associated with development.
Study of epigenetic modifications associated with environmental factors and biological conditions of interest.
Multidisciplinary expertise in genomics, bioinformatics and molecular biology.
Full support from experimental planning through to delivery of results.
Oxford Nanopore Technology for whole-genome long-read sequencing.
We collaborate with academic groups, clinics and industry to adapt the workflow to each research need.
Probiomics supports epigenomic research projects through complete workflows for DNA modification analysis,
from experimental planning to biological interpretation of results.
Tell us briefly about your project or analytical need.
Our scientific team will evaluate your request and get back to you.
Tell us briefly about your project or analytical need.
Our scientific team will evaluate your request and get back to you.
